Vandezande L M, Lamblin C, Wallaert B
Service de Pneumologie et Immuno-allergologie, Hôpital Calmette, Lille.
Rev Mal Respir. 1997 Sep;14(4):327-9.
Fluoxetine (Prozac) is a new anti-depressant introduced on the marked in France since 1989. We report a case of a patient who developed progressive dyspnea without any other symptoms who had been treated with Prozac for nine months. Clinical examination found bilateral basal crepitations. Laboratory assessments showed evidence of inflammation (ESR: 50 mm per hour; CRP 8.9 mg/l), the pulmonary radiograph and thoracic CT scan showed evidence of bilateral diffused interstitial disease. There was also a restrictive ventilatory defect (TLC 59 per cent predicted; FEV1 79 per cent predicted; FVC 70 per cent predicted), effort hypoxaemia and alveolar hyperlymphocytosis (35 per cent). The clinical, radiological and pulmonary function improved and the bronchoalveolar lavage became normal three months after stopping Prozac suggesting a role for this drug in the genesis of this interstitial pneumonia.
氟西汀（百忧解）是自1989年起在法国上市的一种新型抗抑郁药。我们报告了一例患者，该患者在接受氟西汀治疗九个月后出现进行性呼吸困难，无任何其他症状。临床检查发现双侧肺底湿啰音。实验室评估显示有炎症迹象（血沉：每小时50毫米；C反应蛋白8.9毫克/升），胸部X光片和胸部CT扫描显示双侧弥漫性间质性疾病迹象。还存在限制性通气功能障碍（肺总量为预测值的59%；第1秒用力呼气容积为预测值的79%；用力肺活量为预测值的70%）、运动性低氧血症和肺泡淋巴细胞增多（35%）。停用氟西汀三个月后，临床、放射学和肺功能均有改善，支气管肺泡灌洗恢复正常，提示该药物在这种间质性肺炎的发生中起作用。
