Declerck D, Wallaert B, Demarcq-Delerue G, Tonnel A B
Service de Pneumologie et d'Immunologie-allergologie, Hôpital A.-Calmette, Lille.
Rev Mal Respir. 1994;11(3):292-3.
Iatrogenic pneumonias to sulphasalazine are most usually seen during the course of a haemorrhagic proctocolitis (RCH). We report a case in which a young woman was treated with 5-aminosalicylate (Pentasa) and prednisolone during an exacerbation of RCH. After 3 months of treatment the steroid therapy was stopped and the Pentasa was continued at the same dose (3 g per day). She presented with increasing dyspnoea on effort. Clinical examination was normal but a CT scan of the chest showed interstitial micro nodules; there was also a restrictive ventilatory disorder, hypoxaemia on effort and an alveolar eosinophilia (1.8%) The clinical progress, respiratory and blood gases all improved rapidly after stopping the Pentasa with the disappearance of the interstitial nodule over 5 months, suggesting that the role of the Pentasa was causal in the genesis of the pneumonia.
柳氮磺胺吡啶所致的医源性肺炎最常见于出血性直肠结肠炎（RCH）病程中。我们报告一例年轻女性，在RCH病情加重期间接受了5-氨基水杨酸（颇得斯安）和泼尼松龙治疗。治疗3个月后停用类固醇疗法，颇得斯安继续按相同剂量（每日3克）服用。她出现活动时呼吸困难加重。临床检查正常，但胸部CT扫描显示有间质性微小结节；还存在限制性通气障碍、活动时低氧血症和肺泡嗜酸性粒细胞增多（1.8%）。停用颇得斯安后，临床病情、呼吸和血气均迅速改善，5个月期间间质性结节消失，提示颇得斯安在肺炎发生中起因果作用。
