Puchkova L V, Alełnikova T D, Zakharova E T, Tsymbalenko N V, Shirmanova M P
Gałtskhoki VS
Vopr Pitan. 1997(4):19-22.
The concentration of ceruloplasmin decreased about 10 times during the first 20 days of lactation, judging from both immunoelectrophoretic quantitation and oxidase activity measurements. On the other hand, the daily copper consumption per 1 kg of newborn body weight remains constant (about 10 micrograms per day). The artificial fed children receive many folds excesses of the copper ions. The mechanisms, controlling the consumption of copper by newborns via the modulation of ceruloplasmin gene expression in the cells of the lactating mammary gland in the mother are discussed.
从免疫电泳定量和氧化酶活性测量结果来看，哺乳期头20天内，血浆铜蓝蛋白浓度下降了约10倍。另一方面，每1千克新生儿体重每日的铜摄入量保持恒定（约每日10微克）。人工喂养的儿童摄入的铜离子过量许多倍。本文讨论了通过调节母亲乳腺细胞中血浆铜蓝蛋白基因表达来控制新生儿铜摄入量的机制。
