Nonikov V E, Konstantinova T D, Lenkova N I, Minaev V I, Ritchik L A
Antibiot Khimioter. 1997;42(10):15-8.
Step-by-step therapy of patients with pneumonia and exacerbated chronic bronchitis with amoxyclav (amoxycillin/potassium clavulanate) in a dose of 1.2 g administered intravenously dropwise every 8 hours for the first 2 days of the treatment with subsequent oral use of the drug in a dose of 625 mg thrice a day for 5 days proved to be highly efficient. The recovery and improvement were stated in 19 (95 per cent) out of 20 patients. The adverse reaction (urticaria) was observed in 1 patient. Identical results were recorded in a comparative randomized trial with the use of cefotaxime in a dose of 1.0 g intramuscularly every 8 hours for 7 days. The pharmacoeconomic estimate showed the expediency of the step-by-step therapy with the use of amoxycillin/potassium clavulanate.
对于肺炎合并慢性支气管炎急性加重的患者，采用阿莫西林克拉维酸（阿莫西林/克拉维酸钾）进行逐步治疗，在治疗的前2天，以1.2克的剂量每8小时静脉滴注一次，随后口服该药物，剂量为625毫克，每日三次，共5天，结果证明该疗法高效。20名患者中有19名（95%）病情康复或改善。1名患者出现了不良反应（荨麻疹）。在一项对比随机试验中，使用头孢噻肟，剂量为1.0克，每8小时肌肉注射一次，共7天，记录到了相同的结果。药物经济学评估表明，使用阿莫西林/克拉维酸钾进行逐步治疗是合理的。
