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[冠状动脉扩张症中的无症状性心肌缺血。抗凝治疗的效果]

[Asymptomatic ischemia in coronary arterial ectasia. Effects of anticoagulation].

作者信息

Almazán A, Nandayapa O, Rangel A, Badui E, Albarrán H, Lepe L

机构信息

Hospital de Especialidades, Centro Médico La Raza, IMSS, México, D.F.

出版信息

Arch Inst Cardiol Mex. 1997 May-Jun;67(3):195-200.

PMID:9412431
Abstract

We studied 23 patients (22 men and 1 woman), their ages ranged from 31 to 71 years (55.9 +/- 9.7 years), with isolated coronary arterial ectasia. Seventeen patients presented angina pectoris, 19 had myocardial infarction. An angiographic image of intracoronary thrombus was observed in 5 patients. Before the administration of anticoagulants (oral warfarin) 16 patients showed unstable angina, the exercise EKG was positive in 9 patients, and 16 patients presented silent ischemia (showed by EKG-Holter), whose duration was 35.21 +/- 29.27 min per day. After anticoagulants, only 5 patients showed unstable angina pectoris. Exercise EKG was positive in 7 patients and only 7 patients showed silent ischemia, whose duration decreased significantly (P < 0.001) to 12.47 +/- 22.5 min per day.

摘要

我们研究了23例患者(22名男性和1名女性),年龄在31至71岁之间(平均55.9±9.7岁),均患有孤立性冠状动脉扩张。17例患者出现心绞痛,19例发生心肌梗死。5例患者观察到冠状动脉内血栓的血管造影图像。在给予抗凝剂(口服华法林)之前,16例患者表现为不稳定型心绞痛,9例患者运动心电图呈阳性,16例患者出现无症状性心肌缺血(通过动态心电图显示),其持续时间为每天35.21±29.27分钟。给予抗凝剂后,仅5例患者表现为不稳定型心绞痛。7例患者运动心电图呈阳性,仅7例患者出现无症状性心肌缺血,其持续时间显著缩短(P<0.001)至每天12.47±22.5分钟。

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