Baranov V S, Dyban A P
Tsitologiia. 1976;18(5):556-9.
Frequency of aneuploid male gametes was related to the number of early embryos with numeral chromosomal aberrations in progeny of male mice, heterozygous for the Robertsonian translocations T1 (15.6) AID, and T1 (17.8) IEM. In mice heterozygous for translocation T1 (15.6) AID, the number of spermatocytes II with NF=21 was very low and corresponded to the number of trisomic embryos at stages of major organogenesis. In mice heterozygous for T1 (17.8) IEM translocation, the number of aneuploid gametes was 26.2%, but neither embryo of their progeny, on the 8 12th days of gestation, was found to be trisomic. The involvement of chromosomes 8 and 17 in the control of postmeiotic stages of spermatogenesis in mice is suggested.
非整倍体雄配子的频率与雄性小鼠后代中具有数字染色体畸变的早期胚胎数量有关，这些雄性小鼠对罗伯逊易位T1(15.6)AID和T1(17.8)IEM是杂合的。在对易位T1(15.6)AID杂合的小鼠中，二价体数为21的次级精母细胞数量非常少，且与主要器官发生阶段的三体胚胎数量相对应。在对T1(17.8)IEM易位杂合的小鼠中，非整倍体配子的数量为26.2%，但其后代在妊娠第8至12天的胚胎中均未发现三体胚胎。提示8号和17号染色体参与了小鼠精子发生减数分裂后阶段的调控。
