Méndez-Sánchez N, Tanimoto M A, Cobos E, Roldán-Valadez E, Uribe M
Departamento de Gastroenterología, Fundación Clinica Médica Sur, Mexico City, Mexico.
J Clin Gastroenterol. 1997 Oct;25(3):518-21. doi: 10.1097/00004836-199710000-00007.
High levels of cholesterol have been associated with certain gallbladder disorders such as cholesterolosis and gallstone disease. Furthermore, obesity is considered the main risk factor for cholesterol gallstone disease. We investigated the incidence of cholesterolosis in patients with and patients without gallbladder stones (GS). We reviewed the clinical records of patients with gallstone disease and other gallbladder disorders who had consecutive cholecystectomy during a 5-year period. We recorded demographic data, sex, age, serum cholesterol levels, and body mass index. The diagnosis of cholesterolosis was made macroscopically and microscopically. A total of 636 patients were included in this study: 446 with and 190 without GS. Cholesterolosis was more frequent in patients without GS (p < 0.01). However, hypercholesterolemia occurred more frequently in patients with GS (p < 0.001). Obese patients with GS had higher percentages of cholesterolosis and hypercholesterolemia than did eutrophic patients (p < 0.01 and p < 0.05, respectively). We suggest that cholesterolosis in the human gallbladder is not necessarily associated with gallstone disease and high plasma cholesterol levels.
高胆固醇水平与某些胆囊疾病有关，如胆固醇沉着症和胆结石病。此外，肥胖被认为是胆固醇结石病的主要危险因素。我们调查了有和没有胆结石（GS）的患者中胆固醇沉着症的发病率。我们回顾了在5年期间连续接受胆囊切除术的胆结石病和其他胆囊疾病患者的临床记录。我们记录了人口统计学数据、性别、年龄、血清胆固醇水平和体重指数。胆固醇沉着症的诊断通过宏观和微观检查进行。本研究共纳入636例患者：446例有GS，190例无GS。无GS的患者中胆固醇沉着症更为常见（p < 0.01）。然而，高胆固醇血症在有GS的患者中更为常见（p < 0.001）。患有GS的肥胖患者中胆固醇沉着症和高胆固醇血症的百分比高于营养正常的患者（分别为p < 0.01和p < 0.05）。我们认为，人类胆囊中的胆固醇沉着症不一定与胆结石病和高血浆胆固醇水平相关。
