Braghetto I, Antezana C, Hurtado C, Csendes A
Department of Surgery, University of Chile, Santiago.
Am J Surg. 1988 Jul;156(1):26-8. doi: 10.1016/s0002-9610(88)80163-6.
Cholesterol gallstone disease is frequent in Chile compared with other countries, as is cholesterolosis of the gallbladder. The purpose of this study was to determine any differences in bile composition and cholesterol content in the gallbladder wall and serum of patients compared with findings in patients with gallstones and control subjects. In control subjects, cholesterol content of the gallbladder wall was determined in autopsy material. Patients with cholesterolosis had bile composition similar to that of patients with gallstones, with supersaturation of cholesterol in the bile. Also, these patients had increased levels of cholesterol in the gallbladder wall but normal serum cholesterol levels. These findings suggest that altered bile composition occurs in patients with cholesterolosis and gallstones.
与其他国家相比，胆固醇性胆结石疾病在智利较为常见，胆囊胆固醇沉着症也是如此。本研究的目的是确定患者胆囊壁和血清中的胆汁成分及胆固醇含量与胆结石患者和对照受试者的结果相比是否存在差异。在对照受试者中，通过尸检材料测定胆囊壁的胆固醇含量。患有胆固醇沉着症的患者胆汁成分与胆结石患者相似，胆汁中胆固醇过饱和。此外，这些患者胆囊壁中的胆固醇水平升高，但血清胆固醇水平正常。这些发现表明，胆固醇沉着症和胆结石患者的胆汁成分发生了改变。
