Jilma B, Eichler H G, Stohlawetz P, Dirnberger E, Kapiotis S, Wagner O F, Schütz W, Krejcy K
Department of Clinical Pharmacology, TARGET, Vienna, Austria.
Immunobiology. 1997 Nov;197(5):505-12. doi: 10.1016/S0171-2985(97)80082-4.
Based on previous studies showing an increase in circulating soluble intercellular adhesion molecule-1 (sICAM-1) after exercise, we hypothesized that exercise may also increase serum levels of the vascular cell adhesion molecule-1 (sVCAM-1) and sE-selection. In a prospective controlled clinical trial, serum levels of sE-selectin, sICAM-1 and sVAM-1 were measured before and after two different exercise protocols in healthy untrained men. Lactate levels increased up to 12.7 mmol/L (95% confidence interval: 10.1-15.9) and 3.6 mmol/L (CI: 2.4-4.7) after ergometry and after an one hour endurance exercise at 60% of the maximal work intensity, respectively (p = 0.028 vs baseline and controls). The maximal increase in lymphocyte counts of 106% (CI: 63-146), which was only of short duration, was higher immediately after ergometry as compared to that observed after endurance exercise (p = 0.028). However, the maximal increase in neutrophil counts of 178% (CI: 120-298) which was seen at 2 hours after endurance exercise was higher than that seen after ergometry (p = 0.028). In contrast, only small changes of circulating adhesion molecules were seen immediately after ergometry: sICAM-1 increased by 11% (CI: 4-25; p = 0.028), and similar tendencies were also observed for sVCAM-1 and sE-selectin. No other consistent and time-dependent changes of circulating adhesion molecules were observed and all differences and changes were < or = 11%. In sum our study provides evidence that recreational sporting activities in untrained healthy subjects at normal altitude have little influence on serum levels of the circulating vascular adhesion molecules sE-selectin, sVCAM-1 or sICAM-1.
基于先前的研究表明运动后循环可溶性细胞间黏附分子-1（sICAM-1）增加，我们推测运动也可能增加血管细胞黏附分子-1（sVCAM-1）和sE-选择素的血清水平。在一项前瞻性对照临床试验中，对健康的未经训练的男性在两种不同运动方案前后测定sE-选择素、sICAM-1和sVAM-1的血清水平。在进行测力计运动后以及在最大工作强度的60%进行一小时耐力运动后，乳酸水平分别升高至12.7 mmol/L（95%置信区间：10.1 - 15.9）和3.6 mmol/L（CI：2.4 - 4.7）（与基线和对照组相比，p = 0.028）。测力计运动后淋巴细胞计数的最大增幅为106%（CI：63 - 146），且仅持续较短时间，与耐力运动后相比，测力计运动后立即更高（p = 0.028）。然而，耐力运动后2小时观察到的中性粒细胞计数最大增幅为178%（CI：120 - 298），高于测力计运动后（p = 0.028）。相比之下，测力计运动后立即循环黏附分子仅有微小变化：sICAM-1增加11%（CI：4 - 25；p = 0.02），sVCAM-1和sE-选择素也观察到类似趋势。未观察到循环黏附分子的其他一致且随时间变化的变化，所有差异和变化均≤11%。总之，我们的研究提供证据表明正常海拔下未经训练的健康受试者进行休闲体育活动对循环血管黏附分子sE-选择素、sVCAM-1或sICAM-1的血清水平影响很小。
