Faculty of Health and Medical Sciences, University of Surrey , Guildford, UK.
J Sports Sci Med. 2010 Dec 1;9(4):538-46. eCollection 2010.
High levels of physical activity have been linked to benefits in cardiovascular and bone health by affecting, in part, changes in proinflammatory profile. Therefore, we have aimed to assess the effects of intensive training on markers of inflammation, endothelial activation and auto-immunity in the absence of the potential confounding effects of incident atherosclerosis. The subjects comprised 25 competitive gymnasts and 19 healthy sedentary adolescent females, aged 8-17 years. Serum soluble intercellular adhesion molecule 1 (sICAM-1), high sensitivity C-reactive protein (hsCRP), heat shock protein 27 (Hsp27) and Hsp27 antibody titres were measured by ELISAs in a sample of adolescent girls who were either physically active (competitive gymnasts) or sedentary. The association between age, body mass index (BMI), dietary intake, serum hsCRP, sICAM-1 and Hsp27 antigen and antibody titres were determined. The mean serum sICAM-1 concentrations were significantly higher in the gymnasts compared to the sedentary females (0.29 ± 0.02 versus 0.23 ± 0.01 mg·L(-1), p < 0.01). In contrast serum hsCRP concentrations were substantially lower in the gymnasts compared to the sedentary adolescent females (0.49 ± 0.03 versus 1.38 ± 0.19 mg·L(-1), p < 0.001). Differences remained significant after adjustment for anthropometric factors. We also found that serum Hsp27 antigen concentrations were determined by dietary saturated fat intake (p < 0.001), and antibody titres to Hsp27 were determined by dietary PUFA (p < 0.001) after adjustment for BMI. Our findings show that young female gymnasts have an altered profile of inflammatory markers and endothelial activation compared to their less physically active peers. Key pointsResults showed that adolescent young female gymnasts have an altered serum inflammatory markers and endothelial activation, compared to their less physically active peers.Physical activities improved immune system.Differences in these biochemical data kept significant after adjustment for body weight and height.
高水平的身体活动通过影响促炎谱的变化，与心血管和骨骼健康益处相关。因此，我们旨在评估强化训练对炎症标志物、内皮细胞激活和自身免疫的影响，而不存在动脉粥样硬化的潜在混杂影响。研究对象包括 25 名竞技体操运动员和 19 名健康的久坐不动的青少年女性，年龄在 8-17 岁之间。通过酶联免疫吸附试验（ELISA）测量了青少年女孩的血清可溶性细胞间黏附分子 1（sICAM-1）、高敏 C 反应蛋白（hsCRP）、热休克蛋白 27（Hsp27）和 Hsp27 抗体滴度。在身体活跃（竞技体操运动员）或久坐不动的青少年女性中，确定了年龄、体重指数（BMI）、饮食摄入、血清 hsCRP、sICAM-1 和 Hsp27 抗原和抗体滴度之间的关系。竞技体操运动员的血清 sICAM-1 浓度明显高于久坐不动的女性（0.29 ± 0.02 与 0.23 ± 0.01mg·L(-1)，p < 0.01）。相比之下，竞技体操运动员的血清 hsCRP 浓度明显低于久坐不动的青少年女性（0.49 ± 0.03 与 1.38 ± 0.19mg·L(-1)，p < 0.001）。在调整了人体测量因素后，差异仍然显著。我们还发现，血清 Hsp27 抗原浓度取决于饮食中的饱和脂肪摄入量（p < 0.001），而 Hsp27 抗体滴度取决于饮食中的多不饱和脂肪酸（p < 0.001），在调整了 BMI 后。我们的研究结果表明，与不太活跃的同龄人相比，年轻的女体操运动员具有不同的炎症标志物和内皮细胞激活特征。关键点研究结果表明，与不太活跃的同龄人相比，年轻的女体操运动员具有不同的血清炎症标志物和内皮细胞激活特征。身体活动改善了免疫系统。这些生化数据的差异在调整体重和身高后仍然显著。
