Srilatha B, Adaikan P G, Ng S C, Aulkumaran S
Department of Obstetrics & Gynaecology, National University Hospital, National University of Singapore, Singapore.
Methods Find Exp Clin Pharmacol. 1997 Sep;19(7):489-92.
Healthy, nonobese, young rabbits developed hypercholesterolemia following daily intake of fresh egg yolk for 8 weeks. On a quantitative basis, this diet had a profound effect on serum cholesterol level which rose to 15 or 30 times the baseline value depending on whether the test group consumed the yolk content of one or two eggs during the study. Similar drastic changes observed in low density lipoprotein cholesterol levels in these test animals make this a useful method for defining the early pathological changes of atherosclerosis in man. In addition, the present study provides direct evidence of the deleterious effect of hen's egg yolk on the serum cholesterol level in an appropriate and easily reproducible animal model.
健康、非肥胖的幼兔在连续8周每日摄入新鲜蛋黄后出现了高胆固醇血症。从定量角度来看，这种饮食对血清胆固醇水平有深远影响，根据试验组在研究期间食用一个或两个鸡蛋的蛋黄量，血清胆固醇水平升至基线值的15倍或30倍。在这些试验动物中观察到的低密度脂蛋白胆固醇水平的类似剧烈变化，使得这成为一种确定人类动脉粥样硬化早期病理变化的有用方法。此外，本研究在一个合适且易于复制的动物模型中提供了直接证据，证明了鸡蛋黄对血清胆固醇水平的有害影响。
