Tappayuthpijarn P, Dejatiwongse Q, Hincheranan T, Suriyant P N
J Med Assoc Thai. 1989 Aug;72(8):448-51.
The effect of shallot extract on blood lipid levels and erythrocyte shape has been studied in rabbits. Hypercholesterolemia was induced by feeding egg yolk 12.5 g per day for 4 weeks. These rabbits were then divided into 3 groups and were fed with egg yolk alone as control group, egg yolk plus clofibrate 75 mg per day and egg yolk plus 50 g of fresh shallot extract per day respectively. Blood samples were collected from the ear artery every two weeks for evaluating lipid levels and studying morphology of erythrocytes. The abnormal erythrocyte shape (crenation) was strikingly observed in all groups after four weeks of egg yolk feeding with good correlation to lipid levels (r = 0.9, p less than 0.001). The number of crenated erythrocytes decreased continuously by shallot extract from the second week until the eighth week of treatment. This restoring effect could not be seen in the control and clofibrate groups. Lipids levels in all 3 groups did not decrease significantly. This leads to the assumption that there might be some factors other than the lipid-lowering-effect in shallot extract that protect the erythrocyte membrane from deterioration due to high plasma lipid levels.
在兔子身上研究了青葱提取物对血脂水平和红细胞形态的影响。通过每天喂食12.5克蛋黄，持续4周来诱导高胆固醇血症。然后将这些兔子分为3组，分别单独喂食蛋黄作为对照组，每天喂食蛋黄加75毫克氯贝丁酯，以及每天喂食蛋黄加50克新鲜青葱提取物。每两周从耳动脉采集血样，以评估血脂水平并研究红细胞形态。在喂食蛋黄4周后，所有组中均明显观察到异常的红细胞形态（皱缩），且与血脂水平具有良好的相关性（r = 0.9，p小于0.001）。从治疗的第二周直到第八周，青葱提取物使皱缩红细胞的数量持续减少。在对照组和氯贝丁酯组中未观察到这种恢复作用。所有3组的血脂水平均未显著降低。这导致推测，青葱提取物中可能存在除降脂作用以外的某些因素，可保护红细胞膜免受高血浆脂质水平导致的恶化。
