外毛细胞膜马达引起的电流噪声谱和电容：理论
Current noise spectrum and capacitance due to the membrane motor of the outer hair cell: theory.
作者信息
Iwasa K H
机构信息
LCB, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892-0922, USA.
出版信息
Biophys J. 1997 Dec;73(6):2965-71. doi: 10.1016/S0006-3495(97)78325-5.
Abstract
The voltage-dependent motility of the outer hair cell is based on a membrane motor densely distributed in the lateral membrane. The gating charge of the membrane motor is manifested as a bell-shaped membrane potential dependence of the membrane capacitance. In this paper it is shown that movements of the gating charge should produce a high-pass current noise described by an inverse Lorentzian similar to the one shown by Kolb and Läuger for ion carriers. The frequency dependence of the voltage-dependent capacitance is also derived. These derivations are based on membrane motor models with two or three states. These two models lead to similar predictions on the capacitance and current noise. It is expected that the examination of the spectral properties of these quantities would be a useful means of determining the relaxation time for conformational transitions of the membrane motor.
摘要
外毛细胞的电压依赖性运动基于密集分布在侧膜中的膜马达。膜马达的门控电荷表现为膜电容对膜电位的钟形依赖性。本文表明，门控电荷的移动应产生一种高通电流噪声，其由类似于科尔布和劳格所展示的离子载体的反洛伦兹曲线来描述。还推导了电压依赖性电容的频率依赖性。这些推导基于具有两个或三个状态的膜马达模型。这两个模型对电容和电流噪声产生相似的预测。预计对这些量的光谱特性进行研究将是确定膜马达构象转变弛豫时间的有用方法。
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本文引用的文献
1
Force generation in the outer hair cell of the cochlea.耳蜗外毛细胞中的力产生。
Biophys J. 1997 Jul;73(1):546-55. doi: 10.1016/S0006-3495(97)78092-5.
2
Effect of stress on the membrane capacitance of the auditory outer hair cell.应激对听觉外毛细胞膜电容的影响。
Biophys J. 1993 Jul;65(1):492-8. doi: 10.1016/S0006-3495(93)81053-1.
3
Charge displacement induced by rapid stretch in the basolateral membrane of the guinea-pig outer hair cell.豚鼠外毛细胞基底外侧膜快速拉伸诱导的电荷位移
Proc Biol Sci. 1994 Mar 22;255(1344):243-9. doi: 10.1098/rspb.1994.0035.
4
A membrane motor model for the fast motility of the outer hair cell.
J Acoust Soc Am. 1994 Oct;96(4):2216-24. doi: 10.1121/1.410094.
5
Can membrane proteins drive a cell?膜蛋白能驱动细胞吗？
Biophys J. 1995 Apr;68(4 Suppl):214S.
6
High-frequency motility of outer hair cells and the cochlear amplifier.外毛细胞的高频运动与耳蜗放大器
Science. 1995 Mar 31;267(5206):2006-9. doi: 10.1126/science.7701325.
7
Membrane tension directly shifts voltage dependence of outer hair cell motility and associated gating charge.膜张力直接改变外毛细胞运动性及相关门控电荷的电压依赖性。
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8
Induced capacitance in the squid giant axon. Lipophilic ion displacement currents.乌贼巨大轴突中的感应电容。亲脂性离子位移电流。
J Gen Physiol. 1983 Sep;82(3):331-46. doi: 10.1085/jgp.82.3.331.
9
Evoked mechanical responses of isolated cochlear outer hair cells.离体耳蜗外毛细胞的诱发机械反应。
Science. 1985 Jan 11;227(4683):194-6. doi: 10.1126/science.3966153.
10
On the mechanism of a high-frequency force generator in outer hair cells isolated from the guinea pig cochlea.豚鼠耳蜗外毛细胞高频力发生器的机制研究
Proc R Soc Lond B Biol Sci. 1988 Jan 22;232(1269):413-29. doi: 10.1098/rspb.1988.0004.
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