Lyall F, Greer I A
Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow Royal Infirmary, UK.
Rev Reprod. 1996 May;1(2):107-16. doi: 10.1530/ror.0.0010107.
Hypertensive disorders of pregnancy affect up to 15% of pregnancies and the most severe form, pre-eclampsia, is the leading cause of maternal death in the UK today. Pre-eclampsia is a multisystem disorder affecting virtually every organ and system in the body, with hypertension and proteinuria, the traditional diagnostic features, representing two facets of a complex pathophysiological process. The common pathological feature of the disease, whether in the decidual vessels of the placental bed, renal microvasculature, liver, heart or cerebral circulation, is vascular endothelial damage and dysfunction. Before new ways of preventing or ameliorating hypertensive disorders of pregnancy can be found, we must first understand the pathophysiological mechanisms underlying the clinical problem. This review summarizes the evidence that endothelial dysfunction plays a key role in hypertensive disorders of pregnancy and will focus on the most severe form, pre-eclampsia.
妊娠期高血压疾病影响着多达15%的妊娠，其最严重的形式——子痫前期，是当今英国孕产妇死亡的主要原因。子痫前期是一种多系统疾病，几乎影响身体的每个器官和系统，高血压和蛋白尿这两个传统诊断特征是复杂病理生理过程的两个方面。该疾病的共同病理特征，无论是在胎盘床的蜕膜血管、肾微血管、肝脏、心脏还是脑循环中，都是血管内皮损伤和功能障碍。在找到预防或改善妊娠期高血压疾病的新方法之前，我们必须首先了解该临床问题背后的病理生理机制。本综述总结了内皮功能障碍在妊娠期高血压疾病中起关键作用的证据，并将重点关注最严重的形式——子痫前期。
