Campo M S
Beatson Institute for Cancer Research, CRC Beatson Laboratories, Glasgow, Scotland, UK.
Vet J. 1997 Nov;154(3):175-88. doi: 10.1016/s1090-0233(97)80019-6.
Bovine papillomavirus (BPV) induces papillomas of cutaneous or mucosal epithelia in cattle. The papillomas are benign tumours and generally regress, but occasionally persist and provide the focus for malignant transformation to squamous cell carcinoma, particularly in the presence of environmental cofactors. This has been experimentally demonstrated for BPV-2 and cancer of the urinary bladder, and BPV-4 and cancer of the upper alimentary canal in cattle feeding on bracken fern. In this review, several aspects of the biology of the virus are described including viral genome structure, regulation of transcription of the viral oncogenes, function of the viral oncoproteins, cooperation between virus and chemical cofactors in carcinogenesis, virus latency and prophylactic and therapeutic vaccination programmes.
牛乳头瘤病毒（BPV）可诱发牛皮肤或黏膜上皮的乳头瘤。这些乳头瘤是良性肿瘤，通常会自行消退，但偶尔会持续存在，并成为向鳞状细胞癌恶性转化的病灶，尤其是在存在环境辅助因素的情况下。这已在实验中得到证实，如BPV - 2与牛膀胱癌，以及BPV - 4与食用蕨类植物的牛的上消化道癌之间的关系。在这篇综述中，描述了该病毒生物学的几个方面，包括病毒基因组结构、病毒癌基因转录的调控、病毒癌蛋白的功能、病毒与化学辅助因素在致癌过程中的协同作用、病毒潜伏以及预防和治疗性疫苗接种计划。
