Eichler J, Houghten R A
Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA.
Mol Med Today. 1995 Jul;1(4):174-80. doi: 10.1016/s1357-4310(95)91867-1.
The use of combinatorial chemistry is fundamentally changing the pace and scope of basic research and drug discovery. Since the introduction of synthetic peptide libraries several years ago, combinatorial chemistry has proven to be a powerful tool for the generation of immense molecular diversities of peptides, peptidomimetics and new organic compounds. This article briefly reviews methods for the generation and application of combinatorial libraries, with particular emphasis on soluble synthetic combinatorial libraries. The utility of these molecular diversities for basic research and drug discovery has been demonstrated through the identification of numerous highly active compounds such as antigenic peptides, receptor ligands, antimicrobial compounds and enzyme inhibitors.
组合化学的应用正在从根本上改变基础研究和药物发现的速度与范围。自从几年前引入合成肽库以来，组合化学已被证明是一种强大的工具，可用于生成肽、肽模拟物和新有机化合物的巨大分子多样性。本文简要回顾了组合文库的生成方法和应用，特别强调了可溶性合成组合文库。通过鉴定众多高活性化合物，如抗原肽、受体配体、抗菌化合物和酶抑制剂，已证明了这些分子多样性在基础研究和药物发现中的实用性。
