Nefzi A, Dooley C, Ostresh J M, Houghten R A
Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA.
Bioorg Med Chem Lett. 1998 Sep 8;8(17):2273-8. doi: 10.1016/s0960-894x(98)00412-0.
Modified dipeptides have been used successfully for the generation of a variety of small organic and heterocyclic combinatorial libraries, including linear urea, polyamine, hydantoin, thiohydantoin, cyclic urea, cyclic thiourea and bicyclic guanidine. The synthesis and screening results for a number of these libraries are described. The solid phase synthesis of heterocyclic compounds such as diazepine and thiomorpholinone are also described.
修饰二肽已成功用于生成各种小型有机和杂环组合文库，包括线性脲、多胺、乙内酰脲、硫代乙内酰脲、环脲、环硫脲和双环胍。描述了其中一些文库的合成和筛选结果。还描述了杂环化合物如二氮杂卓和硫代吗啉酮的固相合成。
