经阴道羊膜腔穿刺术用于稽留流产的细胞遗传学评估。

Transvaginal amniotic puncture for cytogenetic evaluation of missed abortions.

作者信息

Zilberstein M, Seibel M M

机构信息

Faulkner Center for Reproductive Medicine, Boston, Mass. 02130, USA.

出版信息

Gynecol Obstet Invest. 1997;44(4):217-20. doi: 10.1159/000291531.

DOI:10.1159/000291531

PMID:9415516

Abstract

Transvaginal amniotic puncture (TAP) was performed on 20 consecutive missed abortions immediately prior to dilatation and evacuation and the cytogenetic results compared. The information received from products of conception (POC) and TAP was in concordance in only 5 of 20 (25%) cases. Tissue obtained from POC yielded cells in all instances. However, only 3 of 20 POC samples yielded findings other than normal female. In contrast, 92.8% of the conclusive diagnoses would have been achieved by TAP alone. These data strongly suggest that TAP is superior to POC for accurate cytogenetic assessment of missed abortion and should lead to a reevaluation of our current understanding and management of pregnancy loss.

摘要

在20例连续稽留流产患者行扩张刮宫术前立即进行经阴道羊膜穿刺术（TAP），并比较细胞遗传学结果。仅20例中的5例（25%），从妊娠产物（POC）获得的信息与TAP一致。在所有情况下，从POC获得的组织都能产生细胞。然而，20份POC样本中只有3份产生了非正常女性的结果。相比之下，仅通过TAP就能得出92.8%的确切诊断。这些数据强烈表明，在对稽留流产进行准确的细胞遗传学评估方面，TAP优于POC，这应该促使我们重新评估目前对妊娠丢失的认识和处理方式。