Toman M, Svoboda M, Rybnícek J, Krejcí J, Faldyna M, Bárta O
Veterinary Research Institute, Brno, Czech Republic.
Vet Med (Praha). 1997 Oct;42(10):299-306.
The occurrence of decreased activity of the immune system was studied in a group of 66 dogs with various combinations of pyoderma and demodicosis. Our complex examination of the dogs included the following: leukocyte count, differential count, phagocytosis, blastogenic lymphocyte transformation and quantitation of total serum immunoglobulins, lysozyme and haemolytic complement. Immunosuppression was found in 19 (28.8%) cases. Immunosuppression was rare in dogs with demodicosis and did not appear without a concurrent pyoderma. An increase in the neutrophil counts and total serum immunoglobulin levels significant was found in dogs with demodicosis combined with pyoderma. On the contrary, marked immunosuppression was detected in dogs with deep pyoderma. A considerable immunosuppression was present in 7 of 10 German shepherds dog pyoderma (GSP). Significant depressions were found in phagocyte activity and lymphocyte activity. Immunosuppression was observed in 4 of 9 dogs in other breeds with uncomplicated deep pyoderma. All groups of dogs with pyoderma showed a significant increase in total serum immunoglobulins. Conclusion from these findings is that deep pyoderma more than Demodicosis was concerned with immunosuppression. German shepherds with deep pyoderma had more expressed immunosuppression than other breeds.
对一组66只患有脓疱病和蠕形螨病不同组合的犬进行了免疫系统活性降低情况的研究。我们对这些犬的综合检查包括以下内容：白细胞计数、分类计数、吞噬作用、淋巴细胞增殖转化以及血清总免疫球蛋白、溶菌酶和溶血补体的定量分析。在19例（28.8%）中发现了免疫抑制。免疫抑制在患有蠕形螨病的犬中很少见，且若无并发脓疱病则不会出现。在患有蠕形螨病合并脓疱病的犬中，发现中性粒细胞计数和血清总免疫球蛋白水平显著升高。相反，在深部脓疱病的犬中检测到明显的免疫抑制。10只德国牧羊犬脓疱病（GSP）中有7只存在相当程度的免疫抑制。吞噬细胞活性和淋巴细胞活性明显降低。在其他品种的9只患有单纯深部脓疱病的犬中，有4只观察到免疫抑制。所有患有脓疱病的犬组血清总免疫球蛋白均显著升高。这些研究结果的结论是，深部脓疱病比蠕形螨病更易导致免疫抑制。患有深部脓疱病的德国牧羊犬比其他品种表现出更明显的免疫抑制。
