Latimer K S, Prasse K W, Mahaffey E A, Dawe D L, Lorenz M D, Duncan J R
Am J Vet Res. 1983 Apr;44(4):601-5.
Neutrophilic movement was studied in dogs with atopy, 3 bacterial pyoderma syndromes, flea allergy dermatitis, and generalized demodicosis. Random neutrophil movement was decreased in generalized demodicosis, and this deficit correlated with the extent of body surface skin lesions. Neutrophilic chemotactic movement was decreased in 2 bacterial pyoderma syndromes: bacterial pyoderma, and staphyloccocal pyoderma. Although serum samples from diseased dogs showed no significant differences in chemoattractive qualities from normal pooled canine serum, control canine neutrophils incubated in demodectic dog serum showed decreased chemotactic responsiveness. It was postulated that demodectic dog serum had an inhibitor or deactivator of neutrophil chemotaxis.
对患有特应性皮炎、三种细菌性脓皮病综合征、跳蚤过敏性皮炎和全身性蠕形螨病的犬只的嗜中性粒细胞运动进行了研究。全身性蠕形螨病中随机嗜中性粒细胞运动减少，且这种缺陷与体表皮肤病变的程度相关。在两种细菌性脓皮病综合征（细菌性脓皮病和葡萄球菌性脓皮病）中嗜中性粒细胞趋化运动减少。尽管患病犬只的血清样本与正常混合犬血清在化学吸引特性上无显著差异，但在蠕形螨病犬血清中孵育的对照犬嗜中性粒细胞趋化反应性降低。据推测，蠕形螨病犬血清含有嗜中性粒细胞趋化作用的抑制剂或失活剂。
