Belov A D, Lysenko N P
Radiats Biol Radioecol. 1997 Sep-Oct;37(5):772-9.
The hypothalamic-hypophyseal-cortical multifetal sheep system reaction was examined to respond the sharp single action X-rays dosed 0.96 and 3.84 Gr. The primary irradiation answer was accompanied by expressed hypercorticoidism, which essentially increased with irradiation dose rising and followed the induction of CRF-hypothalamic activity. The secondary sheep hypercorticoidism preceded the clinico-hematomancy and depended on irradiation dose. Hypercorticoidism-2 resulted in blood free bioactive cortisol content increasing. The compensative decrease of named system activity favoured to beam illness outcome. It the prognosis was poor the free and reached its peek before animal death. These data can be used as a test for beam illness outcome prognosis.
研究了下丘脑 - 垂体 - 皮质多胎绵羊系统对剂量为0.96和3.84戈瑞的单次尖锐X射线照射的反应。初次照射反应伴有明显的高皮质醇血症，其随着照射剂量的增加而显著增加，并伴随着促肾上腺皮质激素释放因子（CRF）下丘脑活性的诱导。绵羊的继发性高皮质醇血症先于临床血液学变化，且取决于照射剂量。高皮质醇血症2导致血液中游离生物活性皮质醇含量增加。该系统活性的代偿性降低有利于射线病的转归。如果预后不良，游离皮质醇会增加并在动物死亡前达到峰值。这些数据可作为射线病转归预后的一项检测指标。
