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[接受超致死剂量辐射的大型实验动物辐射病临床表现的定量特征。狗和猴子的内分泌系统反应]

[Quantitative characteristics of radiation sickness clinical manifestations in large-sized laboratory animals exposed to extra-lethal radiation doses. The endocrine system reactions in dogs and monkeys].

作者信息

Korotkevich A O

机构信息

State Research Center of Russia-Institute of Biophysics, Moscow.

出版信息

Radiats Biol Radioecol. 1998 Jul-Aug;38(4):522-34.

PMID:9765670
Abstract

The dynamics of cortisol, insulin and triiodothyronine content of the blood has been studied in dogs and two monkey species exposed to electron and gamma-neutron radiations in a wide supralethal--dose range. A calculated value--index of the endocrine status--has been used for integral estimation the function of the endocrine system. A considerable disintegration of the functions of separate endocrine glands has been observed, which correlates with degree of clinical manifestations in animals and radiation dose.

摘要

对处于超致死剂量范围的电子和γ - 中子辐射下的犬类和两种猴类动物，研究了其血液中皮质醇、胰岛素和三碘甲状腺原氨酸含量的动态变化。利用一个计算值——内分泌状态指数——对内分泌系统功能进行整体评估。观察到各内分泌腺功能有相当程度的瓦解，这与动物的临床表现程度和辐射剂量相关。

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