Lançon C, Farisse J, Llorca P M
Service Hospitalo-Universitaire de Psychiatrie, CHU Sainte-Marguerite, Marseille.
Encephale. 1997 Sep;23 Spec No 4:7-11.
The efficacy of conventional neuroleptics in the treatment of the negative symptoms of schizophrenia is highly controversial. Clozapine, the leading atypical neuroleptic, has been shown to be effective, in the majority of the controlled studies, on both the positive and negative symptoms of the disease. It appears to be active vis-à-vis both the primary and secondary negative symptoms. However, several weeks (at least 12) are required for the effect on primary negative symptoms to clearly emerge. The position of clozapine in the treatment of patients presenting with a state of deficiency remains more debatable.
传统抗精神病药物治疗精神分裂症阴性症状的疗效极具争议。氯氮平作为主要的非典型抗精神病药物，在大多数对照研究中已显示对该疾病的阳性和阴性症状均有效。它似乎对原发性和继发性阴性症状都有作用。然而，对原发性阴性症状产生明显效果需要数周时间（至少12周）。氯氮平在治疗存在缺陷状态患者中的地位仍更具争议性。
