Serrano M
Department of Immunology and Oncology, Centro Nacional de Biotecnología, CSIC, Madrid, Spain.
Exp Cell Res. 1997 Nov 25;237(1):7-13. doi: 10.1006/excr.1997.3824.
The tumor suppressor protein p16INK4a (inhibitor of CDK4) is one of the most direct links between cell-cycle control and cancer. The p16INK4a gene is frequently inactivated in human tumors, and inheritance of mutant alleles results in susceptibility to several types of cancer. p16INK4a is part of a cell-cycle regulatory pathway that converges in the tumor suppressor protein Rb. The mechanisms that regulate p16INK4a are starting to be characterized.
肿瘤抑制蛋白p16INK4a（细胞周期蛋白依赖性激酶4抑制剂）是细胞周期调控与癌症之间最直接的联系之一。p16INK4a基因在人类肿瘤中经常失活，突变等位基因的遗传会导致对多种癌症的易感性。p16INK4a是细胞周期调节途径的一部分，该途径在肿瘤抑制蛋白Rb中汇聚。调节p16INK4a的机制正开始得到阐明。
