Larsen C J
CNRS, IBMIG, Poitiers.
Bull Cancer. 1998 Apr;85(4):304-6.
The p16INK4a gene located in the MTS1 (multiple tumor suppressor 1) locus encodes two proteins, p16INK4a and p19ARF, which are structurally unrelated but functionally similar as both inhibit cell cycle progression. In this review, we report and comment new data obtained from mice knockouted for p19ARF without interfering with the expression of p16INK4a. This results in the rapid occurrence of a spectrum of tumors. These data establish that p19ARF is a genuine tumor suppressor protein and raise the questions of the relationship between the two proteins and their respective importance in malignancies.
位于MTS1（多肿瘤抑制因子1）基因座的p16INK4a基因编码两种蛋白质，即p16INK4a和p19ARF，它们在结构上不相关，但功能相似，因为两者都抑制细胞周期进程。在本综述中，我们报告并评论了从小鼠中获得的新数据，这些小鼠敲除了p19ARF，而不干扰p16INK4a的表达。这导致一系列肿瘤迅速发生。这些数据证实p19ARF是一种真正的肿瘤抑制蛋白，并提出了这两种蛋白质之间的关系及其在恶性肿瘤中各自重要性的问题。
