Feo F, Canuto R A, Torrielli M V, Garcea R, Dianzani M U
Agents Actions. 1976 Feb;6(1-3):135-42. doi: 10.1007/BF01972197.
Treatment for 11-13 weeks with a cholesterol-rich diet induced increases in free and esterified serum cholesterol. There was also an increase in free cholesterol of peritoneal macrophages. A 2.2 times rise in the cholesterol to phospholipid ratio of plasma membranes occurred in cholesterol-enriched macrophages. No changes were observed in phagolysosomes. Cholesterol-enriched macrophages showed a 35.8% inhibition of latex particles phagocytosis. When lipid droplets were substituted for latex the inhibition was 81.7%.
用富含胆固醇的饮食治疗11至13周可导致血清游离胆固醇和酯化胆固醇增加。腹膜巨噬细胞的游离胆固醇也有所增加。富含胆固醇的巨噬细胞中质膜的胆固醇与磷脂比率升高了2.2倍。吞噬溶酶体未观察到变化。富含胆固醇的巨噬细胞对乳胶颗粒吞噬作用的抑制率为35.8%。当用脂滴替代乳胶时，抑制率为81.7%。
