León-Velarde F, Mejía O, Palacios J A, Monge C
Universidad Peruana Cayetano Heredia, Dpto. de Ciencias Fisiológicas/Instituto de Investigaciones de la Altura (IIA), Lima, Peru.
Comp Biochem Physiol B Biochem Mol Biol. 1997 Sep;118(1):53-7. doi: 10.1016/s0305-0491(97)00019-9.
High altitude (HA; n = 5) chickens (Gallus gallus) with a high oxygen hemoglobin (Hb) affinity were transported from their birthplace (Puno, Perú 4,000 m) down sea level (Lima, Perú). The in vivo whole blood oxygen affinity (P50) and the eggshell permeability (P) were studied after several months living at sea level and in the first (F1) and second (F2) generations born at sea level. Our approach was to analyze changes in Hb affinity and eggshell permeability, considered as indicators of HA adaptation in birds. Our results show an increase of the P50 values (a decrease in Hb affinity) towards sea-level values. The results in P indicate that this variable increases towards sea level values in the F2 generation. We conclude that in the Andean chicken, a relative "newcomer" to high altitude (no more than 500 years), neither the Hb affinity for oxygen nor the eggshell permeability are invariable indicators of HA adaptation, in contrast with other native high altitude mammals and birds.
将具有高氧血红蛋白（Hb）亲和力的高海拔（HA；n = 5）鸡（原鸡）从其出生地（秘鲁普诺，海拔4000米）运至海平面（秘鲁利马）。在海平面生活数月后以及在海平面出生的第一代（F1）和第二代（F2）中，研究了体内全血氧亲和力（P50）和蛋壳通透性（P）。我们的方法是分析Hb亲和力和蛋壳通透性的变化，将其视为鸟类适应高海拔的指标。我们的结果显示，P50值朝着海平面值增加（Hb亲和力降低）。P的结果表明，在F2代中该变量朝着海平面值增加。我们得出结论，与其他本地高海拔哺乳动物和鸟类相比，对于高海拔相对“新来者”（不超过500年）的安第斯鸡，氧的Hb亲和力和蛋壳通透性都不是适应高海拔的不变指标。
