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对高海拔低氧的遗传反应:秘鲁安第斯山脉鸡(原鸡)的高血红蛋白-氧亲和力

A genetic response to high altitude hypoxia: high hemoglobin-oxygen affinity in chicken (Gallus gallus) from the Peruvian Andes.

作者信息

Velarde F L, Espinoza D, Monge C, de Muizon C

机构信息

Departamento de ciencias fisiologicas, Universidad Peruana Cayetano Heredia, Lima.

出版信息

C R Acad Sci III. 1991;313(9):401-6.

PMID:1756413
Abstract

A population of chicken (Gallus gallus) from the Peruvian Andes (4,000 m) carrying a high hemoglobin-oxygen affinity has been identified. This property remained stable after over 1 year residence at sea level and was transmitted to the descendants born at sea level. Chicken were introduced in South America during the Spanish conquest and therefore their adaptation time to high altitude is less than 500 years. This finding shows that a genotypic change in hemoglobin function can occur in an extremely short evolutionary time and leads to some reflections on the high altitude adaptation of the mammals that migrated to South America during the great Plio-Pleistocene interchange.

摘要

已鉴定出一群来自秘鲁安第斯山脉(海拔4000米)、具有高血红蛋白-氧亲和力的鸡(原鸡)。在海平面居住超过1年后,这种特性保持稳定,并遗传给了在海平面出生的后代。鸡是在西班牙征服时期引入南美洲的,因此它们适应高海拔的时间不到500年。这一发现表明,血红蛋白功能的基因型变化可以在极短的进化时间内发生,并引发了对在大上新世-更新世交替期间迁移到南美洲的哺乳动物高海拔适应的一些思考。

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