评估抗风湿化合物抗炎活性的客观方法。
Objective methods to assess the anti-inflammatory activity of antirheumatic compounds.
作者信息
Katona G
出版信息
Agents Actions. 1976 Feb;6(1-3):346-9. doi: 10.1007/BF01972253.
A review is to be made of the methods currently being used in the assessment of anti-inflammatory compounds in man. Many of the current methods suffer from the disadvantage of being subjective or depend on various outside factors. We will review methods such as arthroscopy, histopathology, electron microscopy, joint scintigraphy and enzyme determinations in synovial fluid. Arthroscopy will be described in detail and its application to the course of the disease and the effect of anti-inflammatory drugs. Joint scintigraphy using radioactive technetium and indium will be described, which we find easy and reproducible. Current work using such parameters as skin temperature and enzyme content of synovial fluid will be described.
本文将对目前用于评估人体抗炎化合物的方法进行综述。当前许多方法存在主观性或依赖各种外部因素的缺点。我们将综述诸如关节镜检查、组织病理学、电子显微镜检查、关节闪烁显像以及滑液中的酶测定等方法。将详细描述关节镜检查及其在疾病进程和抗炎药物效果方面的应用。还将描述使用放射性锝和铟的关节闪烁显像，我们发现这种方法简便且可重复。将介绍目前使用诸如皮肤温度和滑液酶含量等参数的研究工作。
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