Bahar R, Kunishi M, Kayada Y, Yoshiga K
Department of Oral and Maxillofacial Surgery 1, Hiroshima University School of Dentistry, Japan.
Int J Oral Maxillofac Surg. 1997 Dec;26(6):443-6. doi: 10.1016/s0901-5027(97)80010-0.
The change in the expression pattern of CD44 variant 6 (CD44v6) protein in benign, premalignant, and malignant (SCC) oral epithelial lesions was studied immunohistochemically and compared with the pattern in normal mucosa in order to examine whether this gene can serve as a progression marker in patients with SCC. The principal findings is that CD44v6 expression was clearly downregulated in most cases of severe premalignant lesions as well as in most of the SCCs. The staining pattern and intensity varied according to the degree of dysplasia and to the degree of differentiation of the SCCs. Premalignant severe epithelial dysplasia cases with early features of invasion, not yet developed into SCC, showed distinctly downregulated expression of CD44v6 protein whereas hyperplastic and benign epithelial lesions (papilloma) expressed positive staining patterns comparable to those of the normal counterparts. The authors conclude that alteration in CD44v6 may occur as an early event in primary oral SCC development, as well as in premalignant severe epithelial dysplasia. It can thus, be used as a molecular progression marker when screening for oral cancer.
采用免疫组织化学方法研究了CD44变异体6（CD44v6）蛋白在口腔上皮良性、癌前和恶性（鳞状细胞癌，SCC）病变中的表达模式变化，并与正常黏膜中的模式进行比较，以检验该基因是否可作为SCC患者的病情进展标志物。主要研究结果是，在大多数重度癌前病变以及大多数SCC病例中，CD44v6表达明显下调。染色模式和强度根据发育异常程度以及SCC的分化程度而有所不同。具有早期浸润特征但尚未发展为SCC的癌前重度上皮发育异常病例显示CD44v6蛋白表达明显下调，而增生性和良性上皮病变（乳头状瘤）表达的阳性染色模式与正常对应物相当。作者得出结论，CD44v6的改变可能是原发性口腔SCC发生以及癌前重度上皮发育异常过程中的早期事件。因此，在口腔癌筛查时，它可作为一种分子病情进展标志物。
