Maiti R N, Manickam M, Ray A B, Goel R K
Department of Pharmacology, Banaras Hindu University, Varanasi, India.
Indian J Exp Biol. 1997 Jul;35(7):751-3.
Withafastuosin E (WE), a withanolide of Datura fastuosa, has been reported to possess anti-stress activity and augment prostaglandins. The present investigation has been undertaken to evaluate the anti-ulcer activity and its mechanism in various models of experimentally induced ulcers in rats. WE (20 mg/kg, po) reduced the incidence of ulcer and ulcer index significantly in rats. The drug also decreased volume of gastric secretion, acid and peptic output, though it did not affect mucin secretion or mucosal glycoprotein content in terms of total carbohydrate:protein ratio or gastric cell shedding (in terms of gastric juice DNA content) or cell replication (in terms of microgram DNA/mg of protein). The results suggest significant anti-ulcer activity of WE which may be due to its effect on decreasing the offensive acid-pepsin factors.
从曼陀罗中提取的一种醉茄内酯——醉茄素E（WE），据报道具有抗应激活性并能增加前列腺素。本研究旨在评估其在大鼠实验性溃疡的各种模型中的抗溃疡活性及其作用机制。WE（20毫克/千克，口服）可显著降低大鼠溃疡的发生率和溃疡指数。该药物还可减少胃液分泌量、胃酸和胃蛋白酶分泌量，不过在总碳水化合物与蛋白质的比例方面，它对粘蛋白分泌或粘膜糖蛋白含量、胃细胞脱落（以胃液DNA含量衡量）或细胞复制（以微克DNA/毫克蛋白质衡量）没有影响。结果表明WE具有显著的抗溃疡活性，这可能归因于其降低胃酸 - 胃蛋白酶攻击因子的作用。
