Abbas W R, Maiti R N, Goel R K, Bhattacharya S K
Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Indian J Exp Biol. 1998 Feb;36(2):182-6.
GABA and baclofen (BAC), a GABA-mimetic agent, were investigated for antiulcerogenic activity. Orally administered GABA (100 mg/kg) and BAC (10 mg/kg) showed significant ulcer protection when given either alone for one day or for 4 days, or when given together with aspirin (ASP; 200 mg/kg x 3 days) in their 4 days treatment time in pylorus-ligated rats. Both the drugs showed a tendency to increase acid and decrease peptic output, and increased gastric mucus secretion in terms of total carbohydrate to protein ratio (TC:P) in both the above treatment groups. ASP tended to decrease acid and increase peptic output and significantly decreased TC:P ratio. Both GABA and BAC tended to reverse aspirin-induced effects, though they had little per se effect on TC:P ratio of gastric mucosal glycoproteins except an increase in sialic acid content both after one day or four days treatment. No, per se, effect on cell shedding (DNA and protein content of gastric juice) or cell proliferation (DNA/mg protein) was noted with GABA or BAC but the enhanced cell shedding induced by ASP was attenuated by them. ASP was found to enhance cell proliferation. However, neither of drug showed any effect on cell proliferation when given either alone or in combination with ASP. The antiulcerogenic effect of GABA and BAC may be due to their predominant effects on mucosal defensive factors like enhanced mucin secretion and decreased cell shedding or mucosal damage.
研究了γ-氨基丁酸（GABA）和巴氯芬（BAC，一种GABA模拟剂）的抗溃疡活性。在幽门结扎的大鼠中，口服给予GABA（100毫克/千克）和BAC（10毫克/千克），无论是单独给药一天或四天，还是在四天治疗期间与阿司匹林（ASP；200毫克/千克×3天）联合给药，均显示出显著的溃疡保护作用。在上述两个治疗组中，两种药物均表现出增加胃酸分泌和减少胃蛋白酶分泌的趋势，并以总碳水化合物与蛋白质的比例（TC:P）衡量增加了胃黏液分泌。ASP倾向于减少胃酸分泌并增加胃蛋白酶分泌，并显著降低TC:P比值。GABA和BAC均倾向于逆转阿司匹林诱导的效应，尽管它们本身对胃黏膜糖蛋白的TC:P比值影响很小，只是在一天或四天治疗后唾液酸含量有所增加。GABA或BAC本身对细胞脱落（胃液中的DNA和蛋白质含量）或细胞增殖（DNA/毫克蛋白质）均无影响，但它们减弱了ASP诱导的细胞脱落增加。发现ASP可增强细胞增殖。然而，单独给药或与ASP联合给药时，两种药物对细胞增殖均无任何影响。GABA和BAC的抗溃疡作用可能归因于它们对黏膜防御因子的主要作用，如增强黏蛋白分泌、减少细胞脱落或黏膜损伤。
