Geva E, Arava J, Lerner-Geva L, Hareuveni M, Lessing J B, Ballas S, Amit A
Sackler Faculty of Medicine, Tel Aviv University, Israel.
Fertil Steril. 1997 Dec;68(6):1120-4. doi: 10.1016/s0015-0282(97)00395-6.
To assess the relationship between tumor marker carcinoma antigen-125 levels in seminal plasma and serum and fertilization rates in an IVF program, using intracytoplasmic sperm injection (ICSI).
A prospective study.
IVF Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
PATIENT(S): Twenty-five infertile patients with severe oligo-terato-asthenospermia syndrome and 25 fertile male donors.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Serum and seminal plasma carcinoma antigen-125 concentrations and fertilization rate per cycle.
RESULT(S): In the infertile group, the seminal plasma carcinoma antigen-125 levels ranged from 22.0 to 1,284.0 U/mL (mean level +/- SD, 229.9 +/- 274.2 U/mL). In the normospermic fertile male donors, the seminal plasma carcinoma antigen-125 concentrations ranged from 12.2 to 336.7 U/mL (mean level +/- SD, 110.1 +/- 91.6 U/mL). This difference was statistically significant. The mean +/- SD ratio between the seminal plasma/serum carcinoma antigen-125 levels differed significantly between the infertile group (47.9 +/- 61.3) and the fertile male donors (5.7 +/- 3.5). In the infertile group, the ratio between the seminal plasma/serum carcinoma antigen-125 levels was found to be negatively correlated with the oocyte fertilization rate.
CONCLUSION(S): The ratio between carcinoma antigen-125 levels in the seminal plasma and serum may be an indirect marker for male infertility and fertilization rate in IVF treatment using ICSI.
采用卵胞浆内单精子注射（ICSI）技术，评估精液和血清中肿瘤标志物癌抗原-125水平与体外受精（IVF）程序中受精率之间的关系。
一项前瞻性研究。
以色列特拉维夫索拉科斯基医疗中心利兹妇产医院IVF科。
25名患有严重少弱畸精子症综合征的不育患者和25名有生育能力的男性供者。
无。
血清和精液中癌抗原-125浓度以及每个周期的受精率。
在不育组中，精液中癌抗原-125水平范围为22.0至1284.0 U/mL（平均水平±标准差，229.9±274.2 U/mL）。在精液正常的有生育能力男性供者中，精液中癌抗原-125浓度范围为12.2至336.7 U/mL（平均水平±标准差，110.1±91.6 U/mL）。这种差异具有统计学意义。不育组与有生育能力男性供者的精液/血清癌抗原-125水平的平均±标准差比值差异显著。在不育组中，发现精液/血清癌抗原-125水平的比值与卵母细胞受精率呈负相关。
精液和血清中癌抗原-125水平的比值可能是ICSI体外受精治疗中男性不育和受精率的间接标志物。
