Sarrel P M, Wiita B
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA.
Fertil Steril. 1997 Dec;68(6):1125-7. doi: 10.1016/s0015-0282(98)80034-4.
To compare the effects of estrogen with estrogen-androgen treatment on vaginal blood flow velocity and fingertip postocclusive hyperemic blood flow response.
Prospective, randomized, parallel, double-blind study.
Healthy human volunteers in an academic research environment.
PATIENT(S): Postmenopausal women receiving estrogen replacement therapy for at least 12 months and treated with placebo before this investigation.
INTERVENTION(S): Esterified estrogens or esterified estrogen + methyltestosterone were administered orally; laser Doppler velocimetry was used to determine vaginal and fingertip blood flow responses at baseline and after 4 and 8 weeks of daily drug administration.
MAIN OUTCOME MEASURE(S): Fingertip postocclusive area under curve (AUC); vaginal blood flow velocities.
RESULT(S): The AUC for postocclusive fingertip blood flow and vaginal blood flow increased to a greater extent in the estrogen-androgen group, but changes were not statistically significant between groups.
CONCLUSION(S): Estrogen-androgen treatment does not diminish the vasodilator effects of estrogen treatment in postmenopausal women.
比较雌激素与雌激素 - 雄激素联合治疗对阴道血流速度和指尖阻断后充血血流反应的影响。
前瞻性、随机、平行、双盲研究。
学术研究环境中的健康人类志愿者。
接受雌激素替代疗法至少12个月且在本研究前接受安慰剂治疗的绝经后妇女。
口服酯化雌激素或酯化雌激素 + 甲基睾酮；使用激光多普勒测速仪在基线以及每日给药4周和8周后测定阴道和指尖血流反应。
指尖阻断后曲线下面积（AUC）；阴道血流速度。
雌激素 - 雄激素组指尖阻断后血流和阴道血流的AUC增加幅度更大，但两组间变化无统计学意义。
雌激素 - 雄激素联合治疗不会削弱绝经后妇女雌激素治疗的血管舒张作用。
