Keck P E, McElroy S L
Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267-0559, USA.
J Clin Psychiatry. 1997;58 Suppl 14:32-6; discussion 37-8.
Data from recent epidemiologic surveys of community populations indicate that social phobia is a common psychiatric disorder and is associated with substantial functional impairment in a number of patients. Social phobia is also often comorbid with major depression, substance use disorders, and other anxiety disorders. Fortunately, a variety of antidepressant medications have been reported to alleviate the symptoms of social phobia. Controlled studies have shown substantial efficacy for the monoamine oxidase inhibitors phenelzine, moclobemide, and brofaromine and the serotonin selective reuptake inhibitors fluvoxamine and sertraline. Other serotonin reuptake inhibitors and venlafaxine have shown promise in case reports and open trials.
近期社区人群流行病学调查数据表明，社交恐惧症是一种常见的精神障碍，许多患者存在明显的功能损害。社交恐惧症还常与重度抑郁症、物质使用障碍及其他焦虑症共病。幸运的是，据报道多种抗抑郁药物可缓解社交恐惧症症状。对照研究显示，单胺氧化酶抑制剂苯乙肼、吗氯贝胺和溴法罗明以及5-羟色胺选择性再摄取抑制剂氟伏沙明和舍曲林有显著疗效。其他5-羟色胺再摄取抑制剂和文拉法辛在病例报告和开放试验中显示出前景。
