Ewis S A, Abdel-Rahman M S
Department of Pharmacology/Physiology, University of Medicine and Dentistry of New Jersey/New Jersey Medical School, Newark 07103-2714, USA.
J Appl Toxicol. 1997 Nov-Dec;17(6):409-13. doi: 10.1002/(sici)1099-1263(199711/12)17:6<409::aid-jat462>3.0.co;2-b.
Recently there has been growing interest in studying the differences between different classes of antihypertensive drugs in preventing cardiovascular events in diabetic patients. Hypomagnesemia is common in diabetes mellitus, and correlates to its chronic complications and the associated alteration of the antioxidant enzyme activity. Depletion of reduced glutathione (GSH) in the blood has been demonstrated with myocardial injuries associating hypomagnesemia. A previous study has demonstrated a beneficial effect of metformin hydrochloride (Met), an antihyperglycemic drug, on both magnesium (Mg) and GSH levels in diabetic animals. The purpose of this study was to investigate the effect of oral atenolol, metformin (50 and 60 mg kg[-1] day[-1], respectively) and their combination for 14 days on Mg and GSH levels in blood, liver and heart of diabetic male Wistar rats, as these two parameters have been shown to be altered in diabetics and linked to myocardial ischemic injuries. The results of this investigation showed a state of low levels of Mg and GSH in both blood and liver of the diabetic animals. Treatment with atenolol alone did not change these levels significantly, however administration of metformin or atenolol/metformin increased significantly the GSH levels in both liver and blood, and returned the liver Mg content back to normal values.
最近，对研究不同类别抗高血压药物在预防糖尿病患者心血管事件方面的差异的兴趣与日俱增。低镁血症在糖尿病中很常见，并且与其慢性并发症以及抗氧化酶活性的相关改变有关。血液中还原型谷胱甘肽（GSH）的消耗已被证明与低镁血症相关的心肌损伤有关。先前的一项研究表明，降糖药盐酸二甲双胍（Met）对糖尿病动物的镁（Mg）和GSH水平均有有益作用。本研究的目的是研究口服阿替洛尔、二甲双胍（分别为50和60 mg kg[-1] day[-1]）及其组合用药14天对糖尿病雄性Wistar大鼠血液、肝脏和心脏中Mg和GSH水平的影响，因为这两个参数在糖尿病患者中已显示发生改变并与心肌缺血性损伤有关。这项研究的结果显示，糖尿病动物的血液和肝脏中Mg和GSH水平均处于较低状态。单独使用阿替洛尔治疗并没有显著改变这些水平，然而，给予二甲双胍或阿替洛尔/二甲双胍显著提高了肝脏和血液中的GSH水平，并使肝脏Mg含量恢复到正常水平。
