Zbären P, Borisch B, Läng H, Greiner R
Department of Oto-Rhino-Laryngology, Inselspital, Bern, Switzerland.
Otolaryngol Head Neck Surg. 1997 Dec;117(6):688-93. doi: 10.1016/S0194-59989770053-6.
Undifferentiated carcinoma of nasopharyngeal type (lymphoepithelioma) is an extremely rare malignancy in the laryngohypopharyngeal region. We found reports of only 13 such tumors in the English language literature. We present the findings of four additional cases, one hypopharyngeal and three laryngeal in origin. The three laryngeal tumors were characterized by submucosal spread. The tumors were classified T3 (2x) and T4 (2x) with cervical lymph node metastases at initial presentation in all cases. In three of our four cases the Epstein-Barr virus was demonstrated by the Epstein-Barr virus-encoded RNAs in situ hybridization.
鼻咽型未分化癌（淋巴上皮瘤）是喉下咽区域极为罕见的恶性肿瘤。我们在英文文献中仅发现13例此类肿瘤的报道。我们报告另外4例的研究结果，其中1例起源于下咽，3例起源于喉。3例喉肿瘤的特征为黏膜下扩散。所有病例初诊时肿瘤均分类为T3（2例）和T4（2例），伴有颈部淋巴结转移。在我们的4例病例中，有3例通过爱泼斯坦-巴尔病毒编码RNA原位杂交检测到爱泼斯坦-巴尔病毒。
