de Lima Marcos Antonio Pereira, Silva Álife Diêgo Lima, do Nascimento Filho Antônio Carlos Silva, Cordeiro Thiago Lima, Bezerra João Pedro de Souza, Rocha Maria Aline Barroso, Pinheiro Sally de França Lacerda, Pinheiro Junior Roberto Flávio Fontenelle, Gadelha Maria do Socorro Vieira, da Silva Cláudio Gleidiston Lima
School of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Ceará, Brazil.
Ceará Cancer Institute, ICC, Fortaleza 60430-230, Ceará, Brazil.
Pathogens. 2021 Nov 4;10(11):1429. doi: 10.3390/pathogens10111429.
Over the past few decades, several publications have investigated the role of Epstein-Barr virus (EBV) in head and neck squamous cell carcinomas, and an increasing number of them have shown its presence in laryngeal tumors. The purpose of this meta-analysis was to evaluate the association of EBV with laryngeal carcinoma. The search was carried out in two databases, Scopus and PubMed, using the following terms: "Epstein-Barr virus" and "laryngeal carcinoma". A total of 187 records were found, of which 31 were selected for meeting the inclusion and exclusion criteria. The meta-analysis yielded an overall pooled prevalence of 43.72% (95% confidence interval (CI): 34.35-53.08). Studies carried out in Europe and Eurasia had slightly higher pooled prevalence than other subgroups, while the prevalence of studies performed in developed countries was higher than in developing countries (46.37% vs. 34.02%). Furthermore, laryngeal carcinoma occurred almost three times as often among EBV-infected individuals compared to those without EBV infection (odds ratio = 2.86 (95% CI: 1.18-6.90); Begg's test, = 0.843 and Egger's test, = 0.866). Our findings support the idea that EBV is related to laryngeal carcinoma. However, further studies are needed before recognizing a definitive etiological role of EBV in the development and/or progression of laryngeal carcinomas.
在过去几十年中，有几份出版物研究了爱泼斯坦-巴尔病毒（EBV）在头颈部鳞状细胞癌中的作用，并且越来越多的研究表明其存在于喉肿瘤中。本荟萃分析的目的是评估EBV与喉癌的关联。在Scopus和PubMed这两个数据库中进行检索，使用了以下检索词：“爱泼斯坦-巴尔病毒”和“喉癌”。共找到187条记录，其中31条因符合纳入和排除标准而被选中。荟萃分析得出的总体合并患病率为43.72%（95%置信区间（CI）：34.35 - 53.08）。在欧洲和欧亚大陆进行的研究的合并患病率略高于其他亚组，而在发达国家进行的研究的患病率高于发展中国家（46.37%对34.02%）。此外，与未感染EBV的个体相比，EBV感染个体患喉癌的几率几乎是其三倍（优势比 = 2.86（95%CI：1.18 - 6.90）；Begg检验，P = 0.843，Egger检验，P = 0.866）。我们的研究结果支持EBV与喉癌相关的观点。然而，在确定EBV在喉癌发生和/或进展中的明确病因学作用之前，还需要进一步的研究。
