果蝇NURF-55，一种参与组蛋白代谢的WD重复蛋白。
Drosophila NURF-55, a WD repeat protein involved in histone metabolism.
作者信息
Martínez-Balbás M A, Tsukiyama T, Gdula D, Wu C
机构信息
Laboratory of Molecular Cell Biology, National Cancer Institute, Building 37, Room 5E-26, National Institutes of Health, Bethesda, MD 20892-4255, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):132-7. doi: 10.1073/pnas.95.1.132.
Abstract
The Drosophila nucleosome remodeling factor (NURF) is a protein complex of four distinct subunits that assists transcription factor-mediated chromatin remodeling. One NURF subunit, ISWI, is related to the transcriptional regulators Drosophila brahma and yeast SWI2/SNF2. We have determined peptide sequences and isolated cDNA clones for a second NURF component (the 55-kDa subunit). Immunological studies show that p55 is an integral subunit of NURF and is generally associated with polytene chromosomes. The predicted sequence of p55 reveals a WD repeat protein that is identical with the 55-kDa subunit of the Drosophila chromatin assembly factor (CAF-1). Given that WD repeat proteins related to p55 are associated with histone deacetylase and histone acetyltransferase, our findings suggest that p55 and its homologs may function as a common platform for the assembly of protein complexes involved in chromatin metabolism.
摘要
果蝇核小体重塑因子（NURF）是一个由四个不同亚基组成的蛋白质复合体，它协助转录因子介导的染色质重塑。NURF的一个亚基ISWI与转录调节因子果蝇brahma和酵母SWI2/SNF2相关。我们已经确定了第二个NURF组分（55 kDa亚基）的肽序列并分离出了cDNA克隆。免疫学研究表明，p55是NURF的一个组成亚基，并且通常与多线染色体相关。p55的预测序列显示它是一种WD重复蛋白，与果蝇染色质组装因子（CAF-1）的55 kDa亚基相同。鉴于与p55相关的WD重复蛋白与组蛋白去乙酰化酶和组蛋白乙酰转移酶相关，我们的研究结果表明p55及其同源物可能作为参与染色质代谢的蛋白质复合体组装的一个共同平台发挥作用。
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