Obuchowski N A
Cleveland Clinic Foundation, Department of Biostatistics, OH 44195-5196, USA.
Acad Radiol. 1995 Aug;2(8):709-16. doi: 10.1016/s1076-6332(05)80441-6.
Traditionally, multireader receiver operating characteristic (ROC) studies have used a "paired-case, paired-reader" design. The statistical power of such a design for inferences about the relative accuracies of the tests was assessed and compared with alternative designs.
The noncentrality parameter of an F statistic was used to compute power as a function of the reader and patient sample sizes and the variability and correlation between readings.
For a fixed-power and Type I error rate, the traditional design reduces the number of verified cases required. A hybrid design, in which each reader interprets a different sample of patients, reduces the number of readers, total readings, and reading required per reader. The drawback is a substantial increase in the number of verified cases.
The ultimate choice of study design depends on the nature of the tests being compared, limiting resources, a priori knowledge of the magnitude of the correlations and variability and logistic complexity.
传统上，多读者接受者操作特征（ROC）研究采用“配对病例、配对读者”设计。评估了这种设计用于推断测试相对准确性的统计功效，并与其他设计进行了比较。
使用F统计量的非中心参数来计算功效，该功效是读者和患者样本量以及读数之间的变异性和相关性的函数。
对于固定的功效和I型错误率，传统设计减少了所需的验证病例数。一种混合设计，即每个读者解读不同的患者样本，减少了读者数量、总读数以及每个读者所需的读数。缺点是验证病例数大幅增加。
研究设计的最终选择取决于所比较测试的性质、有限的资源、相关性和变异性大小的先验知识以及逻辑复杂性。
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