Sakuma H, Wendland M F, Saeed M, Derugin N, Geschwind J F, Lauerna K, Mintorovitch J, Cavagna F M, Higgins C B
Department of Radiology, University of California, San Francisco 94143-0628, USA.
Acad Radiol. 1995 Oct;2(10):864-70. doi: 10.1016/s1076-6332(05)80062-5.
We monitored the differences in the first passage of gadobenate dimeglumine through normal and ischemic myocardium with left anterior descending (LAD) coronary artery occlusion in dogs.
Dynamic multislice images of the heart were taken on a 1.5-T magnetic resonance (MR) imager. In six normal dogs, inversion recovery (IR)-prepared fast gradient-recalled echo (GRE) images were acquired at five doses of gadobenate dimeglumine (0.005-0.1 mmol/kg). First passage of the contrast medium through normal and acutely ischemic myocardium were monitored in seven dogs subjected to LAD coronary artery occlusion.
IR-prepared GRE images showed a dose-dependent increase in the signal intensity (SI) of the myocardium. In dogs with LAD coronary artery occlusion, there was a significant increase in the SI of normal myocardium (p < .01) than in ischemic myocardium after injection of 0.025 mmol/kg gadobenate dimeglumine.
The first-pass dynamics of gadobenate dimeglumine through normal and ischemic myocardium can be monitored with a multislice acquisition using a clinical MR imager and differentiated between normal and ischemic myocardium in dogs.
我们监测了钆贝葡胺首次通过正常心肌和因左前降支（LAD）冠状动脉闭塞导致的缺血心肌的差异，实验对象为犬类。
在一台1.5-T磁共振（MR）成像仪上获取心脏的动态多层图像。对6只正常犬，在5个钆贝葡胺剂量（0.005 - 0.1 mmol/kg）下采集反转恢复（IR）准备的快速梯度回波（GRE）图像。在7只接受LAD冠状动脉闭塞的犬中监测造影剂首次通过正常和急性缺血心肌的情况。
IR准备的GRE图像显示心肌信号强度（SI）呈剂量依赖性增加。在LAD冠状动脉闭塞的犬中，注射0.025 mmol/kg钆贝葡胺后，正常心肌的SI显著高于缺血心肌（p <.01）。
使用临床MR成像仪通过多层采集可以监测钆贝葡胺通过正常和缺血心肌的首次通过动力学，并区分犬的正常心肌和缺血心肌。
