Croisille Pierre, Revel Didier, Saeed Maythem
Hôpital Cardiologique L. Pradel, Department of Radiology, Creatis, UMR CNRS 5515 & INSERM U630, 59, Boulevard du Doyen Lépine, 69394, Lyon, Montchat, France.
Eur Radiol. 2006 Sep;16(9):1951-63. doi: 10.1007/s00330-006-0244-z. Epub 2006 Apr 22.
This review paper presents, in the first part, the different classes of contrast media that are already used or are in development for cardiac magnetic resonance imaging. A classification of the different types of contrast media is proposed based on the distribution of the compounds in the body, their type of relaxivity and their potential affinity to particular molecules. In the second part, the different uses of the extracellular type of T1-enhancing contrast agent for myocardial imaging is covered from the detection of stable coronary artery disease to the detection and characterization of chronic infarction. A particular emphasis is placed on the clinical use of gadolinium-chelates, which are the universally used type of MRI contrast agent in the clinical routine. Both approaches, first-pass magnetic resonance imaging (FP-MRI) as well as delayed-enhanced magnetic resonance imaging (DE-MRI), are covered in the different situations of acute and chronic myocardial infarction.
本文综述在第一部分介绍了已用于或正在开发用于心脏磁共振成像的不同类型的造影剂。基于化合物在体内的分布、弛豫率类型及其对特定分子的潜在亲和力，对不同类型的造影剂进行了分类。第二部分涵盖了细胞外T1增强型造影剂在心肌成像中的不同用途，从稳定型冠状动脉疾病的检测到慢性梗死的检测和特征描述。特别强调了钆螯合物的临床应用，钆螯合物是临床常规中普遍使用的MRI造影剂类型。在急性和慢性心肌梗死的不同情况下，均涵盖了首次通过磁共振成像（FP-MRI）和延迟增强磁共振成像（DE-MRI）这两种方法。
