Imaizumi S, Arai S, Sakurai Y, Uenohara H, Nishino A
Department of Neurosurgery, Sendai National Hospital.
Neurol Med Chir (Tokyo). 1996 Nov;36(11):775-81; discussion 781-2. doi: 10.2176/nmc.36.775.
Two-dimensional regional cerebral blood flow (rCBF) was measured using the xenon-133 inhalation method, and used to calibrate the rCBF measured by single photon emission computed tomography (SPECT) in the non-affected middle cerebral artery (MCA) area. The value of the rCBF in the target area could then be measured by SPECT and compared between patients. Technetium-99m-d,l-hexamethyl-propylene-amine-oxime and technetium-99m-diethylenetriaminepenta-acetic acid-human serum albumin D were used to measure rCBF and regional cerebral blood volume (rCBV), respectively, in the ischemic area of 16 patients who underwent surgical revascularization in the chronic stage. No significant increase in rCBF was obtained after the bypass surgery. The delta rCBF and delta CBF/CBV ratio correlated well with the extent of vascularization in the MCA area on postoperative angiograms. Patients with a low CBF/CBV ratio on preoperative SPECT scans tended to show favorable postoperative vascularization and rCBF in the MCA area. Since the angiographic findings and the delta rCBF or delta CBF/CBV were correlated well, this simple and non-invasive method could be used for the analysis of rCBF in a group of patients.
采用氙-133吸入法测量二维局部脑血流量（rCBF），并用于校准非患侧大脑中动脉（MCA）区域通过单光子发射计算机断层扫描（SPECT）测量的rCBF。然后可通过SPECT测量目标区域的rCBF值，并在患者之间进行比较。分别使用锝-99m-d，l-六甲基丙烯胺肟和锝-99m-二乙三胺五乙酸人血清白蛋白D测量16例在慢性期接受手术血运重建患者缺血区域的rCBF和局部脑血容量（rCBV）。搭桥手术后rCBF未获得显著增加。术后血管造影显示，ΔrCBF和ΔCBF/CBV比值与MCA区域的血管化程度密切相关。术前SPECT扫描显示CBF/CBV比值低的患者，术后MCA区域往往显示出良好的血管化和rCBF。由于血管造影结果与ΔrCBF或ΔCBF/CBV密切相关，这种简单且无创的方法可用于一组患者的rCBF分析。
