Bell W R, Tomasulo P A, Alving B M, Duffy T P
Ann Intern Med. 1976 Aug;85(2):155-60. doi: 10.7326/0003-4819-85-2-155.
In a group of 52 patients receiving continuous intravenous heparin, 16 developed thrombocytopenia (platelets less than 100 000/mm3). Ten of the 16 patients who had thrombocytopenia had elevated titers of fibrinogen-fibrin degradation products, and five of these 10 patients also had a reduction in plasma fibrinogen. The abnormalities disappeared after the heparin preparation was discontinued. These occurrences could not be attributed to drugs other than heparin, to the dose of heparin administered, or to prior exposure to heparin. The mechanism by which the heparin preparation may induce these changes is not known.
在一组接受持续静脉注射肝素的52例患者中，16例出现血小板减少（血小板计数低于100000/mm³）。16例血小板减少患者中有10例纤维蛋白原-纤维蛋白降解产物滴度升高，这10例患者中有5例血浆纤维蛋白原也降低。停用肝素制剂后，这些异常情况消失。这些情况不能归因于肝素以外的药物、所使用的肝素剂量或既往接触肝素的情况。肝素制剂可能诱发这些变化的机制尚不清楚。
