脊髓内吗啡肽-1和内吗啡肽-2对大鼠背角神经元诱发反应的不同抑制作用。
Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat.
作者信息
Chapman V, Diaz A, Dickenson A H
机构信息
Department of Pharmacology, University College London.
出版信息
Br J Pharmacol. 1997 Dec;122(8):1537-9. doi: 10.1038/sj.bjp.0701594.
Abstract
Intrathecal endomorphin-1 and endomorphin-2 (0.25-50 micrograms) dose-relatedly reduced all components of electrical evoked C-fibre responses of spinal neurones. These effects were partially reversed by naloxone. Endomorphin-1, but not endomorphin-2, dose-relatedly reduced the A beta-fibre evoked responses. Peak inhibitory effects of endomorphin-1 and -2 were at 15-20 min post-administration. Thus spinal endomorphin-2 had selective effects on noxious responses, whereas endomorphin-1 was non-selective.
摘要
鞘内注射内吗啡肽-1和内吗啡肽-2（0.25 - 50微克）剂量依赖性地降低了脊髓神经元电诱发C纤维反应的所有成分。这些作用被纳洛酮部分逆转。内吗啡肽-1剂量依赖性地降低Aβ纤维诱发的反应，而内吗啡肽-2则无此作用。内吗啡肽-1和-2的最大抑制作用出现在给药后15 - 20分钟。因此，脊髓内吗啡肽-2对伤害性反应具有选择性作用，而内吗啡肽-1则无选择性。
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