Nikanne E, Kokki H, Tuovinen K
Department of Otorhinolaryngology, Kuopio University Hospital, Finland.
Br J Anaesth. 1997 Nov;79(5):606-8. doi: 10.1093/bja/79.5.606.
We have investigated if ketoprofen 0.5 mg kg-1 i.v. provided as good analgesia with less adverse effects compared with ketoprofen 2.0 mg kg-1 i.v. in 107 children, aged 1-7 yr, after adenoidectomy, in a randomized, double-blind, parallel group study design. A standard anaesthetic method was used and all children received fentanyl 1 microgram kg-1 i.v. during induction. Children in group 2.0 received ketoprofen 2.0 mg kg-1 and children in group 0.5, 0.5 mg kg-1 i.v. during induction. If the child was in pain, fentanyl 1 microgram kg-1 was given i.v. as rescue analgesia. We found that ketoprofen provided good analgesia and only 49% of children required fentanyl in the post-anaesthesia care unit. There were no differences between the groups in the number of fentanyl doses, pain scores or frequency of adverse reactions. No serious adverse reactions occurred.
在一项随机、双盲、平行组研究设计中，我们调查了107名1至7岁行腺样体切除术的儿童，静脉注射0.5毫克/千克酮洛芬与静脉注射2.0毫克/千克酮洛芬相比，是否能提供同样良好的镇痛效果且副作用更少。采用标准麻醉方法，所有儿童在诱导期间静脉注射1微克/千克芬太尼。2.0组儿童在诱导期间静脉注射2.0毫克/千克酮洛芬，0.5组儿童静脉注射0.5毫克/千克。如果儿童疼痛，静脉注射1微克/千克芬太尼作为急救镇痛。我们发现酮洛芬提供了良好的镇痛效果，在麻醉后护理单元中只有49%的儿童需要芬太尼。两组在芬太尼剂量、疼痛评分或不良反应频率方面没有差异。未发生严重不良反应。
