Murase K, Tsuda T, Mochizuki T, Tanada S, Ikezoe J
Department of Radiology, Ehime University School of Medicine, Japan.
Nucl Med Commun. 1997 Nov;18(11):1049-56. doi: 10.1097/00006231-199711000-00008.
This study was performed to evaluate the application of spectral analysis (SA) to hepatobiliary dynamic scintigraphy with 99Tcm-N-pyridoxyl-5-methyltryptophan (99Tcm-PMT) in 82 patients with a wide range of liver function, and to compare it with compartment analysis (CA) and deconvolution analysis (DA). The rate of uptake of PMT by the liver from the blood (k1) obtained by SA (y, min-1) agreed well with the k1 value obtained using CA (x, min-1) (y = 1.079x + 0.000, r = 0.993, standard error of the estimate (S.E.E.) = 0.042 min-1). The mean residence time (MRT) of PMT in the liver obtained by SA (y, min) also agreed well with the MRT value obtained by DA (x, min) (y = 1.036x - 0.759, r = 0.967, S.E.E.-1.014 min) and that obtained by CA (x, min) (y = 0.859x + 1.006, r = 0.931, S.E.E. = 1.428 min). The fraction of the measured blood activity superimposed on the true liver activity (f) obtained by SA (y) correlated well with the f value obtained by CA (x) (y = 1.168x - 0.004, r = 0.924, S.E.E. = 0.043). We conclude that the application of SA to hepatobiliary dynamic scintigraphy with PMT appears to be useful in evaluating the functional status of the liver, since it facilitates the interpretation of the kinetic behaviour of PMT in the liver and allows us to extract quantitative parameters corresponding to those obtained by CA or DA.
本研究旨在评估光谱分析（SA）在82例肝功能范围广泛的患者中应用于99锝-N-吡哆醛-5-甲基色氨酸（99锝-PMT）肝胆动态闪烁显像的情况，并将其与房室分析（CA）和反卷积分析（DA）进行比较。通过SA获得的肝脏从血液中摄取PMT的速率（k1）（y，分钟-1）与使用CA获得的k1值（x，分钟-1）吻合良好（y = 1.079x + 0.000，r = 0.993，估计标准误差（S.E.E.）= 0.042分钟-1）。通过SA获得的PMT在肝脏中的平均滞留时间（MRT）（y，分钟）也与通过DA获得的MRT值（x，分钟）吻合良好（y = 1.036x - 0.759，r = 0.967，S.E.E. = 1.014分钟）以及与通过CA获得的MRT值（x，分钟）吻合良好（y = 0.859x + 1.006，r = 0.931，S.E.E. = 1.428分钟）。通过SA获得的叠加在真实肝脏活性上的测量血液活性分数（f）（y）与通过CA获得的f值（x）相关性良好（y = 1.168x - 0.004，r = 0.924，S.E.E. = 0.043）。我们得出结论，将SA应用于PMT肝胆动态闪烁显像似乎有助于评估肝脏的功能状态，因为它有助于解释PMT在肝脏中的动力学行为，并使我们能够提取与通过CA或DA获得的参数相对应的定量参数。
