基于编码多核苷酸中可能的密码子-密码子互补性，氨基酸序列中出现广泛的信息对称性。
The occurrence in amino acid sequences of extensive informational symmetries based on possible codon-codon complementarity in the encoding polynucleotides.
作者信息
Polya G M, Phillips D R
出版信息
Biochem J. 1976 Mar 1;153(3):681-90. doi: 10.1042/bj1530681.
Abstract
- A procedure is described for the detection and assessment of informational complementarity in an amino acid sequence; it is based on possible autocomplementarity in the mRNA, and involves codon-to-codon matching. 2. This procedure was applied to myelin basic protein, a variety of protamines, histone IV, silk fibroin, rat skin collagen alpha1 chain and a sheep keratin. A multiplicity of extensive low-probability informational symmetries, based on codon-to-codon matching, were detected. 3. These low-probability orderings, which are independent of the actual mRNA codons, are rationalized in terms of the evolutionary ordering of the amino acid sequences concerned, in such a way that constraints on the secondary structure of the coding polynucleotides were satisfied. This possible interpretation is supported by a number of significant common properties of the protein sequences analysed.
摘要
- 本文描述了一种用于检测和评估氨基酸序列中信息互补性的方法；该方法基于mRNA中可能存在的自身互补性，并涉及密码子对密码子的匹配。2. 此方法应用于髓鞘碱性蛋白、多种鱼精蛋白、组蛋白IV、丝心蛋白、大鼠皮肤胶原蛋白α1链和一种绵羊角蛋白。基于密码子对密码子的匹配，检测到了多种广泛的低概率信息对称性。3. 这些与实际mRNA密码子无关的低概率排序，根据相关氨基酸序列的进化排序进行了合理化解释，从而满足了对编码多核苷酸二级结构的限制。这种可能的解释得到了所分析蛋白质序列的一些显著共同特性的支持。
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