Shmarov D A, Kuchma Iu M, Kozinets G I
Ter Arkh. 1997;69(7):17-21.
Cell cycle stage distribution of bone marrow cells was studied at flow cytometry in 137 hematological patients. They had acute lymphoblastic leukemia, acute myeloblastic leukemia, lymphosarcoma with leukemization, blast crisis of chronic myeloid leukemia, iron deficiency anemia, pernicious anemia, autoimmune hemolytic anemia, aplastic anemia (31, 34, 18, 12, 17, 8, 9, 8 cases, respectively). It was found that in leukemia, and to a lesser degree in anemia, stability of the cell cycle was impaired. In leukemia onset, recurrence and remission, the proportion S/(G2+M) appeared increased evidencing defective DNA synthesis by myelokaryocytes and ineffective hemopoiesis. Similar changes were seen in pernicious and aplastic anemia.
采用流式细胞术研究了137例血液病患者骨髓细胞的细胞周期阶段分布情况。这些患者分别患有急性淋巴细胞白血病、急性髓细胞白血病、伴有白血病化的淋巴肉瘤、慢性髓细胞白血病急变期、缺铁性贫血、恶性贫血、自身免疫性溶血性贫血、再生障碍性贫血（分别为31、34、18、12、17、8、9、8例）。结果发现，在白血病患者中，细胞周期稳定性受损，在贫血患者中受损程度较轻。在白血病发病、复发和缓解期，S/(G2+M)比例升高，表明髓细胞核细胞DNA合成存在缺陷以及造血无效。在恶性贫血和再生障碍性贫血中也观察到类似变化。
