Cohen-Fix O, Koshland D
Howard Hughes Medical Institute, Carnegie Institution of Washington, Baltimore, MD 21210, USA.
Curr Opin Cell Biol. 1997 Dec;9(6):800-6. doi: 10.1016/s0955-0674(97)80080-4.
The metaphase-to-anaphase transition is a highly regulated process, which is governed by the activity of the anaphase-promoting complex (APC). The APC promotes the degradation of several proteins, including mitotic cyclins and newly identified anaphase inhibitors. Several discoveries made this year shed invaluable light on the regulation of APC activation and its substrate specificity.
中期到后期的转变是一个受到高度调控的过程，由后期促进复合物（APC）的活性所控制。APC促进多种蛋白质的降解，包括有丝分裂周期蛋白和新发现的后期抑制因子。今年的几项发现为APC激活的调控及其底物特异性提供了极有价值的线索。
